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Updated: Jan 31, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Identification of targets for prostate cancer immunotherapy

Antonios Papanicolau-Sengos1, Yuanquan Yang2, Sarabjot Pabla1

  • 1OmniSeq, Inc., Buffalo, New York.

The Prostate
|January 8, 2019
PubMed
Abstract

Insights

Profiling the immune microenvironment of prostate cancer (PC) revealed CD276 and the PVR/NECTIN2/CD226/TIGIT pathway as novel immunotherapy targets for castration-resistant (CRPC) and castration-sensitive (CSPC) disease.

Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Prostate cancer (PC) progression involves distinct immune microenvironments in castration-sensitive (CSPC) and castration-resistant (CRPC) stages.
  • Identifying novel immune targets is crucial for developing effective PC immunotherapies.

Purpose of the Study:

  • To profile the immune microenvironment of CSPC and CRPC.
  • To identify novel targets for PC immunotherapy.

Main Methods:

  • Conducted immunohistochemistry, fluorescent in situ hybridization, and RNA-sequencing on 19 PC specimens.
  • Performed targeted genomic sequencing and fusion analysis on 17 specimens.
  • Analyzed immune-related genes, including CD276, PVR, and NECTIN2.

Main Results:

  • CD276, PVR, and NECTIN2 showed high expression in PC.
  • Differential expression of immune-related genes was observed between CRPC and CSPC, and primary versus metastatic tissues.
  • Unsupervised clustering identified two distinct groups correlating with CRPC and CSPC status.

Conclusions:

  • CD276 represents a potential therapeutic target in PC.
  • The PVR/NECTIN2/CD226/TIGIT pathway is implicated in PC immune evasion and represents a novel target for checkpoint inhibition therapies.
Keywords:
CD226CD276NECTIN2PVRTIGITaggressive prostate cancercastration-resistant prostate cancercastration-sensitive prostate cancerimmunotherapy

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