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A meta-analysis on correlations of OX40L variants with atherosclerotic disorders

Xiaoxu Wang1, Yaxin Luan1, Chengsen Zhang2

  • 1Department of Cardiology, The Second Municipal Hospital of Weihai City, Weihai, Shandong, China.

Journal of Cellular Biochemistry
|January 8, 2019
PubMed

Insights

Genetic variants in OX40 ligand (OX40L) show associations with atherosclerotic cardio-cerebral vascular diseases (ASCVD) in specific populations. Certain OX40L variants may serve as biomarkers for coronary artery disease (CAD) and acute coronary syndrome (ACS).

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Immunology

Background:

  • Atherosclerotic cardio-cerebral vascular diseases (ASCVD) represent a significant global health burden.
  • The role of genetic variations, specifically in OX40 ligand (OX40L), in the development of ASCVD requires further investigation.

Purpose of the Study:

  • To conduct a meta-analysis investigating the correlations between OX40 ligand (OX40L) genetic variants and atherosclerotic cardio-cerebral vascular diseases (ASCVD).
  • To identify potential genetic biomarkers for ASCVD subtypes.

Main Methods:

  • Systematic literature search performed across PubMed, Medline, and Embase databases.
  • Meta-analysis and statistical analyses conducted using Review Manager.
  • Inclusion of eighteen studies for comprehensive analysis.

Main Results:

  • Overall analysis showed no significant correlation between OX40L variants and ASCVD.
  • Subgroup analysis by ethnicity revealed a significant association between the rs1234314 variant and ASCVD in East Asians.
  • Specific variants (rs17568, rs1234314, rs3850641) showed significant associations with acute coronary syndrome (ACS) and coronary artery disease (CAD) subtypes.

Conclusions:

  • The rs17568, rs1234314, and rs3850641 variants of OX40L may function as genetic biomarkers for specific types of coronary artery disease (CAD).
  • Further research is warranted to elucidate the precise mechanisms underlying these genetic associations.
Abstract

Keywords:
OX40 ligand (OX40L)atherosclerotic cardio-cerebral vascular diseases (ASCVD)coronary artery disease (CAD)genetic variantsischemic stroke (IS)meta-analysis

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