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Expression and clinical significance of miR-139-5p in non-small cell lung cancer

You Yong-Hao1,2, Wang Xian-Guo1, Xu Ming1

  • 11 Department of Thoracic and Cardiovascular Surgery, Zhongnan Hospital Affiliated to Wuhan University, Wuhan, Hubei, China.

The Journal of International Medical Research
|January 8, 2019
PubMed
Abstract

Insights

MicroRNA-139-5p (miR-139-5p) is down-regulated in non-small cell lung cancer (NSCLC) tissues. Low miR-139-5p expression correlates with advanced NSCLC stages and poorer survival outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression.
  • MiR-139-5p is recognized as a tumor-suppressive miRNA across various cancers.
  • Its role in non-small cell lung cancer (NSCLC) warrants further investigation.

Purpose of the Study:

  • To quantify miR-139-5p expression in NSCLC tissues.
  • To investigate the correlation between miR-139-5p levels and clinicopathological parameters in NSCLC patients.
  • To assess the prognostic value of miR-139-5p in NSCLC.

Main Methods:

  • Quantitative real-time PCR was employed to measure miR-139-5p expression.
  • Sixty NSCLC patients' cancerous and adjacent normal tissues were analyzed.
  • Statistical analyses, including t-tests and univariate analysis, were performed.

Main Results:

  • MiR-139-5p expression was significantly lower in NSCLC tissues compared to normal tissues.
  • Down-regulation of miR-139-5p correlated with advanced clinical stage, pathological type, larger tumor size, and lymph node metastasis.
  • Low miR-139-5p expression was associated with reduced overall survival.

Conclusions:

  • MiR-139-5p is frequently down-regulated in NSCLC.
  • Reduced miR-139-5p expression serves as a potential biomarker for advanced disease and poor prognosis in NSCLC.
  • MiR-139-5p may function as a tumor suppressor in the development of NSCLC.
Keywords:
Non-small cell lung cancerclinical stagefluorescence quantitative PCRlymph node metastasismiR-139-5pmiRNApathological typesurvivaltumor sizetumor suppressor gene

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