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Long non-coding RNAs differential expression in breast cancer subtypes: What do we know?
Carolina Mathias1, Erika P Zambalde1, Philip Rask2
1Department of Genetics, Federal University of Parana, Curitiba, Brazil.
Clinical Genetics
|January 8, 2019
Summary
This review explores long non-coding RNAs (lncRNAs) in breast cancer (BC) subtypes. Differentially expressed lncRNAs contribute to BC heterogeneity and show potential as diagnostic biomarkers.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Breast cancer (BC) is a leading cause of cancer death in women and a heterogeneous disease.
- BC is classified into four subtypes: luminal A, luminal B, ERBB2-positive, and triple-negative.
- Long non-coding RNAs (lncRNAs) are implicated in various diseases, including BC.
Purpose of the Study:
- To review lncRNAs with differential expression across BC subtypes.
- To explore the role of these lncRNAs in contributing to BC heterogeneity.
- To highlight the potential of lncRNAs as biomarkers for BC.
Main Methods:
- Literature review focused on lncRNAs and BC subtypes.
- Analysis of studies reporting differential lncRNA expression in BC.
- Examination of research on lncRNA functions in BC pathogenesis.
Main Results:
- lncRNAs exhibit distinct expression patterns across different BC subtypes.
- Specific lncRNAs are associated with the molecular and clinical characteristics of BC subtypes.
- lncRNAs play roles in BC development, progression, and treatment resistance.
Conclusions:
- lncRNAs are crucial in understanding BC heterogeneity.
- lncRNAs represent promising biomarkers for BC classification and prognosis.
- Targeting lncRNAs may offer novel therapeutic strategies for breast cancer.
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