Related Experiment Video

Updated: Jan 31, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

21.1K

Review shows substantial variations in the use of medication for infant bronchiolitis between and within countries

Matti Korppi1, Minna Mecklin1, Paula Heikkilä1

  • 1Center for Child health Research, Tampere University Hospital, University of Tampere, Tampere, Finland.

Acta Paediatrica (Oslo, Norway : 1992)
|January 8, 2019
PubMed

Insights

Medication use for infant bronchiolitis varies significantly worldwide, despite evidence not supporting its effectiveness. This review highlights inconsistent real-world treatment practices in hospitals globally.

Area of Science:

  • Pediatrics
  • Respiratory Medicine
  • Evidence-Based Medicine

Background:

  • Randomized controlled trials indicate no benefit from medication for infant bronchiolitis.
  • Real-world medication use in hospitalized infants with bronchiolitis remains under-examined.

Purpose of the Study:

  • To summarize current data on the real-life use of medications for infants hospitalized with bronchiolitis.
  • To evaluate variations in medication administration across different healthcare settings and countries.

Main Methods:

  • A systematic literature search was conducted on PubMed for studies published between 2009 and 2018.
  • Studies focusing on the use of adrenaline, salbutamol, corticosteroids, or antibiotics in infants hospitalized for bronchiolitis were included.

Main Results:

  • Ten studies revealed significant international and intranational variations in medication use for infant bronchiolitis.
  • A multi-center study reported that 29% of infants received non-evidence-based drugs, with rates varying from 9% to 58% across countries.
  • In US pediatric intensive care units (PICUs), bronchodilators were used in 60%, corticosteroids in 33%, and antibiotics in 63% of cases.

Conclusions:

  • Substantial variations exist in the treatment of infant bronchiolitis, both between and within different countries.
  • Current real-world practices often deviate from evidence-based recommendations for infant bronchiolitis management.
Abstract

Keywords:
AdrenalineAntibioticsBronchiolitisCorticosteroidsSalbutamol

More Related Videos

P50 Sensory Gating in Infants12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K
Author Spotlight: Marmoset Research - Scope and Challenges04:52

Author Spotlight: Marmoset Research - Scope and Challenges

Published on: June 9, 2023

2.6K

Related Concept Videos

What is Variation?01:14

What is Variation?

Apart from the measures of central tendency, distribution, outliers, and the changing characteristics of data with time, an important characteristic of any data set is its variation or spread. In some data sets, the data values are concentrated closely near the mean; in others, the data values are more widely spread out from the mean.
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
18.4K
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
Variation01:19

Variation

An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
8.0K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.8K
Variation of Atmospheric Pressure01:18

Variation of Atmospheric Pressure

Change in atmospheric pressure with height is particularly interesting. The decrease in atmospheric pressure with increasing altitude is due to the decreasing gravitational force per unit area as we move away from the surface of the earth.
Assuming the air temperature is constant at a given altitude and that the ideal gas law of thermodynamics describes the atmosphere to a good approximation, one can find the variation of atmospheric pressure with height.
Let p(y) be the atmospheric pressure at...
4.1K