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Updated: Jan 31, 2026

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On the pH-Modulated Ru-Based Prodrug Activation Mechanism

Marco Caterino1, Mona Herrmann2, Antonello Merlino1

  • 1Department of Chemical Sciences , University of Naples Federico II , via Cinthia , Naples I-80126 , Italy.

Inorganic Chemistry
|January 8, 2019
PubMed
Summary

Ruthenium (Ru) prodrug AziRu binds proteins, with release dependent on reduction and reducing agents. Its pH-dependent properties suggest selective cancer cell targeting.

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