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Updated: Jan 31, 2026

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
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Erenumab for episodic migraine prophylaxis.

Lucas Hendrik Overeem1, Lars Neeb1, Uwe Reuter1

  • 1a Department of Neurology and Experimental Neurology , Charite - Universitatsmedizin , Berlin , Germany.

Expert Review of Neurotherapeutics
|January 8, 2019
PubMed
Summary

Erenumab, a CGRP receptor antagonist, effectively prevents migraines by reducing monthly migraine days. This treatment shows good tolerability and improves patient quality of life.

Keywords:
CGRPCGRP receptorMigraineantibodyerenumabpreventiontreatment failure

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Migraine is a debilitating neurological condition impacting millions globally.
  • Current treatments for migraine prevention have limitations, leading to a need for novel therapies.

Purpose of the Study:

  • To review placebo-controlled randomized double-blind studies of erenumab for migraine prevention.
  • To evaluate the efficacy and tolerability of erenumab in episodic and chronic migraine patients.

Main Methods:

  • Systematic review of English-language articles from PubMed.
  • Search terms included "episodic and chronic migraine," "migraine prophylaxis and prevention," "CGRP," "CGRP receptor antagonist," and "erenumab."

Main Results:

  • Erenumab significantly reduced mean monthly migraine days compared to placebo in Phase II and III trials.
  • Approximately 50% of patients experienced at least a 50% reduction in migraine days.
  • Improved patient-reported outcomes and quality of life were observed.
  • Erenumab demonstrated efficacy in patients with prior treatment failures.
  • The drug exhibited good tolerability with low dropout rates.

Conclusions:

  • Erenumab is an effective and well-tolerated treatment for migraine prevention.
  • It offers a new therapeutic option for patients with episodic and chronic migraine, including those with treatment failures.