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Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Serum Lipids and Risk of Rapid Renal Function Decline in Treated Hypertensive Adults With Normal Renal Function
Xianglin Zhang1, Binyan Wang1,2, Juan Yang3
1Division of Nephrology, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Insights
High triglycerides and TG:HDL-C ratio increase the risk of rapid kidney function decline in hypertensive adults. Lower total cholesterol and LDL-C were associated with a reduced risk.
Area of Science:
- Nephrology
- Cardiology
- Endocrinology
Background:
- Hypertension is a major risk factor for chronic kidney disease.
- Lipid parameters play a crucial role in cardiovascular and renal health.
- Understanding lipid profiles' impact on renal function decline is vital for hypertensive patients.
Purpose of the Study:
- To investigate the association between various lipid parameters and the risk of rapid renal function decline.
- To identify potential effect modifiers in hypertensive patients with normal baseline renal function.
Main Methods:
- Analysis of 12,549 hypertensive patients from the China Stroke Primary Prevention Trial.
- Primary outcome: rapid renal function decline (eGFR decline ≥ 5 ml/min/1.73 m2 per year).
- Median follow-up duration of 4.4 years.
Main Results:
- Higher triglycerides (TG) and TG to HDL-C ratio were significantly associated with increased risk of rapid renal function decline.
- Lower total cholesterol (TC) and LDL-C levels showed a reduced risk.
- Elevated TG risk was more pronounced in individuals with lower total homocysteine levels.
Conclusions:
- Elevated triglycerides and TG:HDL-C ratio are independent risk factors for rapid renal function decline in hypertensive adults.
- Lipid management strategies may be important for preserving kidney function in this population.
- Further research into lipid metabolism and kidney health interactions is warranted.
Background:
We aim to evaluate the effect of different lipids parameters, including triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), the TG to HDL-C (TG:HDL-C) ratio, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), on the risk of rapid renal function decline and examine any possible effect modifiers in general hypertensive patients with normal renal function.
Methods:
A total of 12,549 hypertensive patients with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 in the renal sub-study of the China Stroke Primary Prevention Trial were included in the analyses. The primary outcome was rapid renal function decline, defined as an average decline in eGFR ≥ 5 ml/min/1.73 m2 per year.
Results:
The median treatment duration was 4.4 years. After the full adjustment for TC, TG, HDL-C, and other major covariates, a significantly higher risk of rapid renal function decline was found in participants with higher TG [≥150 vs. <150 mg/dl, 7.7% vs. 5.5%; odds ratios (OR): 1.27; 95% confidence interval (CI): 1.06-1.51], higher TG:HDL-C ratio [≥2.7 (median) vs. <2.7, 7.7% vs. 5.0%; OR: 1.39; 95% CI: 1.14-1.71), lower TC (≥200 vs. <200 mg/dl, 6.0% vs. 7.0%; OR: 0.79; 95% CI: 0.67-0.93), or lower LDL-C levels (≥130 vs. <130 mg/dl, 6.1% vs. 7.0%; OR: 0.79; 95% CI: 0.67-0.94). Moreover, the increased risk of the primary outcome associated with elevated TG was particularly evident among individuals with lower total homocysteine levels [<12.4 (median) vs. ≥ 12.4 μmol/l, P interaction = 0.036].
Conclusions:
Higher TG and TG:HDL-C ratio were independent risk factors for rapid renal function decline in hypertensive adults with normal renal function.
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