Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current problems and future goals in clinical bone marrow transplantation.

S Slavin1, E Kedar

  • 1Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.

Blood Reviews
|December 1, 1988
PubMed
Summary

Allogeneic bone marrow transplantation (BMT) faces challenges like graft-versus-host disease (GVHD) and immune suppression. Novel immunotherapies show promise for enhancing antitumor effects and improving outcomes in both autologous and allogeneic BMT.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interleukin-7 induced facilitation of immunological reconstitution of sublethally irradiated mice following treatment with alloreactive spleen cells in a murine model of B-cell leukemia/lymphoma (BCL1).

Bone marrow transplantation·2007
Same author

Long-term follow-up of high-dose treatment with autologous haematopoietic progenitor cell support in 693 patients with follicular lymphoma: an EBMT registry study.

Leukemia·2007
Same author

Deletion of donor-reactive cells as a new conditioning regimen for allogeneic bone marrow transplantation.

Transplantation proceedings·2007
Same author

Allogeneic hematopoietic stem cell transplantation in the elderly.

Critical reviews in oncology/hematology·2007
Same author

Safety and efficacy of donor lymphocyte infusions following mismatched stem cell transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2006
Same author

Fear appeals and treatment side-effects: an effective combination for HIV prevention?

AIDS care·2006

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Allogeneic bone marrow transplantation (BMT) is limited by toxic chemotherapy, radiation, graft-versus-host disease (GVHD), and delayed immune reconstitution.
  • Autologous BMT often results in high relapse rates due to the absence of allogeneic immune interactions against residual tumor cells.

Purpose of the Study:

  • To explore novel strategies for amplifying antitumor effects in BMT.
  • To investigate the potential of cytokines and lymphokine-activated cells in improving BMT outcomes.
  • To evaluate the role of biological response modifiers in reducing BMT risks.

Main Methods:

  • Review of animal model studies and clinical evidence.
  • Discussion of cytokine-mediated amplification of cellular antitumor effects.

Related Experiment Videos

  • Analysis of in vitro and in vivo cytokine administration in BMT.

    • Main Results:

    • Antileukemic effects of allogeneic grafts may be partially independent of GVHD.
    • Cytokine treatment (including IL-2) shows evidence of antileukemia activity in animal models.
    • Cytokines facilitate immunological and hematopoietic reconstitution in BMT, both in vitro and in vivo.

    Conclusions:

    • Innovative biological interventions, including cytokines and immunomanipulations, offer potential for safer and more effective BMT.
    • Replacing aggressive chemoradiotherapy with sophisticated immunotherapies could significantly advance BMT.
    • Further research is needed to establish these novel approaches for successful BMT.