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Updated: Jan 31, 2026

Cryo-Electron Tomography Remote Data Collection and Subtomogram Averaging
Published on: July 12, 2022
Remote Para-C-H Acetoxylation of Electron-Deficient Arenes
Minghong Li1, Ming Shang1, Hui Xu2
1State Key Laboratory of Organometallic Chemistry , Shanghai Institute of Organic Chemistry , Shanghai 20032 , China.
Abstract:
One formidable challenge in sp2 C-H activation is how to achieve high para selectivity on electron-deficient arenes because such site selectivity is disfavored by the electronic bias induced by the electron-withdrawing groups. The first highly selective para-C-H acetoxylation of various benzoic acids using a nitrile-based template was realized. Removal of the template leads to para-hydroxylated benzoic acids, which are versatile intermediates for a wide range of synthetically useful transformations.
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