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Related Concept Videos

Inertial Frames of Reference01:03

Inertial Frames of Reference

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Newton’s first law is usually considered to be a statement about reference frames. It provides a method for identifying a special type of reference frame: the inertial reference frame. In principle, we can make the net force on a body zero. If its velocity relative to a given frame is constant, then that frame is said to be inertial. So, by definition, an inertial reference frame is a reference frame where Newton's first law holds valid. Newton's first law applies to objects with...
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Non-inertial Frames of Reference01:27

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A reference frame accelerating or decelerating relative to an inertial frame is a non-inertial frame. To help understand this, consider what taking off in an airplane, turning a corner in a car, riding a merry-go-round, and the circular motion of a tropical cyclone all have in common. All these systems are accelerating, decelerating, or rotating relative to the Earth; hence, they all are non-inertial frames. All these systems exhibit inertial forces, which merely seem to arise from motion,...
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Phase Diagrams

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A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
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Chemical Shift: Internal References and Solvent Effects01:17

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In an NMR sample, precise measurement of the absolute absorption frequencies of nuclei is difficult. A standard internal reference compound is added, and the frequency difference between the reference signal and sample signals is measured.
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Phase Transitions

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Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
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Inductance: Single-Phase And Three-Phase Line01:28

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Understanding the inductance of transmission lines is crucial for efficient design and operation in electrical power systems. This discussion delves into the inductance characteristics of single-phase two-wire and three-phase three-wire transmission lines with equal phase spacing.
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Updated: Jan 31, 2026

The ITS2 Database
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INDEX-db: The Indian Exome Reference Database (Phase I).

Husayn Ahmed P1,2, Vidhya V3, Ravi Prabhakar More1

  • 11 Accelerator Program for Discovery in Brain Disorders Using Stem Cells (ADBS), National Centre for Biological Sciences, Tata Institute of Fundamental Research (NCBS-TIFR), Bengaluru, India.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|January 8, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed the Indian Exome database (INDEX-db) to map genetic variations in the Indian population. This resource aids in understanding genotype-phenotype correlations and disease associations across diverse human groups.

Keywords:
Indian populationgenetic variations cataloguepopulation-specific databasewhole exome sequencing

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Area of Science:

  • Genomics
  • Population Genetics
  • Bioinformatics

Background:

  • Deep sequencing advances genetic variant cataloging for disease association studies.
  • Understanding population-specific genetic variation is crucial for genotype-phenotype correlation.
  • Differential selection pressures across populations can affect disease association findings.

Purpose of the Study:

  • To develop phase I of the Indian Exome database (INDEX-db).
  • To create a centralized, integrated database of genetic variations from the Indian population.
  • To provide a foundational resource for researchers studying disease mechanisms.

Main Methods:

  • Deep sequencing for genetic mapping.
  • Database development and integration of genetic variation data.
  • Focus on the Indian population.

Main Results:

  • Establishment of phase I of the INDEX-db.
  • Creation of a reference map of genetic variations within the Indian population.
  • A centralized repository for integrated genetic information.

Conclusions:

  • The INDEX-db is a valuable resource for studying genetic variations in the Indian population.
  • This database facilitates research into genotype-phenotype correlations and disease associations.
  • INDEX-db supports investigations at clinical, genetic, and cellular levels of disease mechanisms.