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Trans-retinal cellular imaging with multimodal adaptive optics.

Zhuolin Liu1, Johnny Tam2, Osamah Saeedi3

  • 1Center for Devices and Radiological Health (CDRH), U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.

Biomedical Optics Express
|January 8, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces a novel multimodal adaptive optics (AO) system combining scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) for enhanced retinal imaging. The new system simplifies design and improves visualization of retinal cells across all depths.

Keywords:
(010.1080) Active or adaptive optics(110.4500) Optical coherence tomography(170.3880) Medical and biological imaging(170.4460) Ophthalmic optics and devices

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Area of Science:

  • Ophthalmology
  • Biomedical Optics
  • Retinal Imaging

Background:

  • Adaptive optics (AO) enhances resolution in retinal imaging.
  • Multimodal AO (mAO) approaches integrate multiple imaging techniques but often face challenges with complexity and diminished individual modality performance.
  • Optimizing information extraction from retinal cells requires matching their properties to imaging modality capabilities.

Purpose of the Study:

  • To present a novel, simplified multimodal AO (mAO) system integrating scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT).
  • To demonstrate the system's capability for flexible scanning modes and independent focus control.
  • To validate the enhanced imaging performance for comprehensive retinal cell visualization.

Main Methods:

  • Development of a novel mAO instrument combining SLO and OCT with a simplified optical design.
  • Implementation of flexible alternation between scanning modes and independent focus control.
  • In vivo imaging of retinal cellular structures in human subjects.

Main Results:

  • The mAO system successfully visualized cells across the entire retinal depth in three human subjects.
  • Detailed imaging included microglia, nerve fiber bundles, retinal ganglion cells, axons, capillaries, foveal cones, peripheral rods, and retinal pigment epithelial cells.
  • The system demonstrated visualization of cells in their natural mosaic arrangement.

Conclusions:

  • The novel mAO system offers a simplified and effective approach for multimodal retinal imaging.
  • This technology enables comprehensive visualization of retinal structures from the inner to outer retina.
  • Multimodal AO is a powerful tool for assessing overall retinal health.