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Updated: Jan 31, 2026

Transcranial Direct Current Stimulation tDCS for Memory Enhancement
Published on: September 18, 2021
Improving working memory and pain inhibition in older persons using transcranial direct current stimulation
Zoha Deldar1, Nabi Rustamov1, Isabelle Blanchette2
1Department of Chiropractic, Université du Québec à Trois-Rivières, 3351 Boul. Des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada; CogNAC Research Group, Université du Québec à Trois-Rivières, 3351 Boul. Des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada.
Transcranial Direct Current Stimulation (tDCS) can improve working memory and pain inhibition in older adults. This non-invasive brain stimulation technique enhanced cognitive performance and pain modulation in participants aged 64 and above.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Gerontology
Background:
- Aging is associated with declines in cognitive functions, including working memory.
- Chronic pain is prevalent in older populations, often exacerbated by cognitive load.
- Non-invasive brain stimulation techniques offer potential therapeutic avenues for age-related cognitive and sensory deficits.
Purpose of the Study:
- To investigate the efficacy of transcranial Direct Current Stimulation (tDCS) in enhancing working memory capacity.
- To determine if tDCS can improve pain inhibition, particularly in conjunction with working memory tasks, among older adults.
- To assess the impact of tDCS on cognitive performance under varying working memory loads in an aging cohort.
Main Methods:
- A within-subject design was employed with fifteen older adults (mean age 64 years).
- Participants underwent two tDCS sessions, performing an n-back task at 0-back and 2-back loads during painful ankle stimulation.
- Five counterbalanced conditions included pain alone, and 0-back or 2-back tasks with or without pain, contrasted with anodal tDCS and sham tDCS.
Main Results:
- Anodal tDCS significantly decreased response times and improved pain inhibition during the 2-back working memory condition (p < 0.01).
- No significant effects of tDCS were observed in the 0-back or pain alone conditions.
- Sham tDCS yielded no significant effects across all conditions (p > 0.3).
Conclusions:
- Transcranial Direct Current Stimulation (tDCS) demonstrates potential for enhancing working memory and pain inhibition in older individuals.
- The benefits of tDCS appear dependent on cognitive load, specifically improving performance in more demanding working memory tasks.
- These findings suggest tDCS as a promising non-invasive intervention for mitigating age-related cognitive decline and improving pain management.
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