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Related Concept Videos

Harmonic Mean01:09

Harmonic Mean

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The arithmetic mean is usually skewed towards the larger values in the data set. Therefore, to avoid this inherent bias towards smaller values, the harmonic mean is used.
Take the example of the speed of a car, which is the measure of the rate of distance traveled. If the vehicle traverses the same distance back-and-forth, its average speed equals the total distance traveled divided by the total time taken. However, if the car moves with varying speeds, then the arithmetic mean is more skewed...
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Simple Harmonic Motion01:21

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Simple harmonic motion is the name given to oscillatory motion for a system where the net force can be described by Hooke's law. If the net force can be described by Hooke's law and there is no damping (by friction or other non-conservative forces), then a simple harmonic oscillator will oscillate with equal displacement on either side of the equilibrium position. To derive an equation for period and frequency, the equation of motion is used. The period of a simple harmonic oscillator is given...
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Energy in Simple Harmonic Motion01:23

Energy in Simple Harmonic Motion

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To determine the energy of a simple harmonic oscillator, consider all the forms of energy it can have during its simple harmonic motion. According to Hooke's Law, the energy stored during the compression/stretching of a string in a simple harmonic oscillator is potential energy. As the simple harmonic oscillator has no dissipative forces, it also possesses kinetic energy. In the presence of conservative forces, both energies can interconvert during oscillation, but the total energy remains...
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What is the Immune System?01:38

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Characteristics of Simple Harmonic Motion01:17

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The key characteristic of the simple harmonic motion is that the acceleration of the system and, therefore, the net force are proportional to the displacement and act in the opposite direction to the displacement. Additionally, the period and frequency of a simple harmonic oscillator are independent of its amplitude. For example, diving boards move faster or slower based on their thickness. A stiff, thick diving board has a large force constant, which causes it to have a smaller period, while a...
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Data Reporting and Recording01:24

Data Reporting and Recording

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Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
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Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
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Harmonizing Immune Effector Toxicity Reporting.

Helen E Heslop1, Elizabeth J Shpall2

  • 1Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, Texas.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|January 8, 2019
PubMed
Summary
This summary is machine-generated.

New guidelines define toxicities from immune effector cell therapies. This includes cytokine release syndrome and immune cell-associated neurotoxicity syndrome, improving patient care and research standardization.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Immune effector cell therapies are advancing rapidly.
  • Associated toxicities require standardized definitions and grading.
Keywords:
GuidelinesImmune effector cellsToxicity

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  • Current classifications lack uniformity across institutions.