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Maturational patterns in right ventricular strain mechanics from the fetus to the young infant

Collin T Erickson1, Philip T Levy2, Mary Craft1

  • 1Department of Pediatric Cardiology and Cardiovascular Surgery, University of Nebraska College of Medicine and Children's hospital and Medical Center, Omaha, NE, United States of America.

Early Human Development
|January 8, 2019
PubMed

Insights

Right ventricular (RV) function shows distinct age-specific development patterns, with strain mechanics changing significantly during gestation and the first year of life. These findings establish normal RV development benchmarks for assessing cardiac health in infants and children.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Fetal Echocardiography

Background:

  • Understanding right ventricular (RV) function development is crucial for diagnosing congenital heart disease.
  • Age-specific patterns of RV mechanics are not well-defined from gestation through infancy.

Purpose of the Study:

  • To investigate the age-specific developmental patterns of RV strain mechanics.
  • To establish normative data for RV function from mid-gestation to one year of age.

Main Methods:

  • Prospective longitudinal study of 50 healthy subjects using 2D-speckle tracking echocardiography (2DSTE).
  • RV function assessed via global and free wall longitudinal strain and strain rate at multiple time points from mid-gestation to one year.
  • Investigated associations with gestational age, postnatal age, fetal weight, body surface area, gender, and heart rate.

Main Results:

  • RV longitudinal strain and strain rate decreased throughout gestation.
  • These measures increased significantly after birth, from one week to one year of age.
  • A consistent base-to-apex gradient in RV segmental longitudinal strain was observed throughout the study period.

Conclusions:

  • RV strain patterns exhibit distinct gestational and postnatal age-specific maturation.
  • These myocardial deformation parameters provide a valid reference for comparing healthy development with cardiac conditions.
Abstract

Keywords:
2D speckle-tracking echocardiographyFetusMyocardial strainNeonatesRight ventricleRight ventricular mechanics

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