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UDP-glucuronosyltransferase genetic variation in North African populations: a comparison with African and European
Apolonia Novillo1, María Gaibar1, Alicia Romero-Lorca1
1a Basic Biomedical Sciences Department , Universidad Europea de Madrid , Madrid , Spain.
Background:
Genetic variation in glucuronosyltransferases (UGT) is crucial in drug metabolism and risk of some diseases.
Aim:
To examine genetic variation in UGT in North African populations.
Subjects And Methods:
Allele frequencies of SNPs UGT1A424Thr, UGT1A448Val, UGT2B1585Tyr, UGT2B15523Thr and UGT2B17 CNV deletion from Morocco, Algeria, Tunisia and Libya were compared to European and Sub-Saharan populations.
Results:
North Africans are the group with the highest genetic heterogeneity given by internal differences in the occurrence of UGT2B17 deletion, UGT1A448Val and UGT1A4 haplotypes. UGT2B15 SNPs differentiate Sub-Saharans from the rest of the populations.
Conclusion:
North African populations show a high frequency of carriers of UGT2B15523Thr, a variant linked to an increased risk of prostate cancer. High Atlas Moroccans and Algerians show low frequency of UGT2B17del, a variant associated with high concentrations of testosterone and oestradiol.
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