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Effect of ultrasound-guided lumbar plexus block on emergence agitation in children undergoing hip surgery: study
Hui Zhang1, Qing Fan2, Junfeng Zhang1
1Department of Anesthesiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, No. 600, Yishan Road, Shanghai, 200233, China.
Insights
Ultrasound-guided lumbar plexus block may reduce emergence agitation (EA) in children undergoing hip surgery. This study investigates its effectiveness compared to fentanyl for preventing EA and improving postoperative outcomes.
Area of Science:
- Pediatric Anesthesiology
- Regional Anesthesia
- Pain Management
Background:
- Emergence agitation (EA) is a common postoperative complication in children, leading to self-injury and behavioral changes.
- Current methods for preventing EA lack a definitive 'gold standard'.
- Pain is a significant contributor to EA, and effective pain management is crucial.
Purpose of the Study:
- To evaluate the efficacy of ultrasound-guided lumbar plexus block in reducing the incidence of EA in pediatric hip surgery patients.
- To compare the effectiveness of lumbar plexus block versus fentanyl in managing EA.
- To assess the impact of the block on postoperative pain and adverse events.
Main Methods:
- Prospective, randomized, controlled, blinded trial involving 100 children (1-6 years) undergoing elective hip surgery.
- Participants randomly assigned to receive either ultrasound-guided lumbar plexus block or fentanyl post-anesthesia induction.
- Primary outcome: incidence of EA measured by the Pediatric Anesthesia Emergence Delirium (PAED) score 30 minutes after emergence.
Main Results:
- The study aims to determine if ultrasound-guided lumbar plexus block significantly decreases EA incidence.
- Secondary outcomes include EA severity and duration, postoperative pain scores, and adverse event rates.
- Data collection includes pre-operative, intra-operative, and post-operative assessments.
Conclusions:
- The hypothesis is that ultrasound-guided lumbar plexus block will reduce EA in pediatric hip surgery.
- This trial seeks to provide clinical evidence to support or refute this hypothesis.
- Confirmation of the hypothesis could establish a novel, safe method for preventing EA.
Background:
Emergence agitation (EA) is a common postoperative issue in children that causes self-injury, increases stress on healthcare team members, and even leads to postoperative maladaptive behavioral changes in children. Clear answers regarding a 'gold standard' for prevention of EA are not available. Pain is regarded as an important causative factor of EA, and ultrasound-guided lumbar plexus block is a safe and efficient anesthetic method that can provide satisfactory pain relief in pediatric hip surgery. The purpose of our study is to determine whether ultrasound-guided lumbar plexus block can reduce the incidence of EA in children undergoing hip surgery.
Methods/Design:
We designed a prospective, randomized, controlled, blinded trial to determine the effect of ultrasound-guided lumbar plexus block on EA. A total of 100 American Society of Anesthesiologists class I-II children (1-6 years old) scheduled for elective hip surgery will be recruited for this study. Participants will be randomized at a 1:1 ratio to receive either ultrasound-guided lumbar plexus block or fentanyl after the induction of general anesthesia. The primary outcome is the incidence of EA 30 min after emergence from anesthesia using the Pediatric Anesthesia Emergence Delirium (PAED) score. The secondary outcomes are the severity and duration of EA 30 min after emergence from anesthesia using the PAED score, postoperative pain evaluated by the Children's Hospital of Eastern Ontario Pain Scale, and the incidence of postoperative adverse events. Randomization will be conducted using a computer-generated randomization schedule. Outcome assessors and data collectors will be blinded to the group allocations. Assessments will be performed before surgery, intraoperatively, and postoperatively at every time point.
Discussion:
Our hypothesis in this trial is that ultrasound-guided lumbar plexus block can decrease the incidence of EA in children undergoing elective hip surgery. This trial will provide clinical answers to verify our hypothesis. If our hypothesis is confirmed, the results could provide a safe method to prevent EA.
Trial Registration:
Chinese Clinical Trial Registry, ChiCTR-INR-17011525 . Registered on 30 May 2017.
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