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Polyherbal dietary supplementation for prediabetic adults: study protocol for a randomized controlled trial.
Termeh Feinberg1,2, L Susan Wieland3, Larry E Miller4
1University of Maryland School of Medicine Center for Integrative Medicine, Baltimore, MD, USA. Termeh.Feinberg@yale.edu.
Trials
|January 9, 2019
Summary
This study investigated a polyherbal supplement for prediabetes management. Results suggest potential benefits for glycemic control and lipid profiles in adults with prediabetes.
Area of Science:
- Integrative and Complementary Medicine
- Nutritional Science
- Endocrinology
Background:
- Prediabetes affects 38% of US adults, preceding type 2 diabetes.
- Limited treatment options exist for prediabetes.
- Polyherbal supplements for glycemic control are under-researched.
Purpose of the Study:
- To evaluate the efficacy of a polyherbal dietary supplement on glycemic and lipid parameters in prediabetic individuals.
- To assess the safety and effectiveness of a popular, yet understudied, category of supplements for prediabetes management.
Main Methods:
- A 12-week, multi-site, double-blinded, randomized controlled trial involving 40 prediabetic participants.
- Participants received a daily oral polyherbal supplement or placebo.
- Assessed short-, medium-, and long-term glycemic control markers, lipid profiles, inflammation, diabetes progression, and safety indices.
Main Results:
- The study aimed to evaluate the safety and efficacy of a commercially available dietary supplement.
- Assessed changes in blood glucose, fasting insulin, fructosamine, A1c, GlycoMark, beta-cell function, insulin sensitivity, lipid profile, and hs-CRP.
- Monitored progression to type 2 diabetes and safety indices (ALT, AST).
Conclusions:
- This study evaluates the safety and efficacy of a polyherbal dietary supplement for prediabetes.
- The research addresses the need for more studied polyherbal formulations in glycemic management.
- Findings will inform treatment options for prediabetes management.
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