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Bilateral NAION and GPIbα gene
Christina S Lim1,2, Ajoy Sarkar3, Christopher Knapp4
1Ophthalmology Department, Lincoln County Hospital, Greetwell Road, Lincoln, Lincolnshire, UK. Christina.sk.lim13@gmail.com.
BMC Ophthalmology
|January 9, 2019
Summary
This study reports a rare case of bilateral non-arteritic anterior ischemic optic neuropathy (NAION) in a patient with two copies of the GPIbα gene VNTR B alleles. This finding highlights a potential genetic risk factor for NAION.
Area of Science:
- Ophthalmology
- Genetics
- Hematology
Background:
- Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of optic nerve damage.
- Previous studies linked one copy of VNTR B alleles of the GPIbα gene to increased NAION risk and fellow eye involvement.
- Bilateral NAION cases are rare, and genetic predispositions are under investigation.
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