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Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Bilateral NAION and GPIbα gene.

Christina S Lim1,2, Ajoy Sarkar3, Christopher Knapp4

  • 1Ophthalmology Department, Lincoln County Hospital, Greetwell Road, Lincoln, Lincolnshire, UK. Christina.sk.lim13@gmail.com.

BMC Ophthalmology
|January 9, 2019
PubMed
Summary

This study reports a rare case of bilateral non-arteritic anterior ischemic optic neuropathy (NAION) in a patient with two copies of the GPIbα gene VNTR B alleles. This finding highlights a potential genetic risk factor for NAION.

Area of Science:

  • Ophthalmology
  • Genetics
  • Hematology

Background:

  • Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of optic nerve damage.
Keywords:
Bilateral optic neuropathyGPIbαPlatelet glycoprotein

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  • Previous studies linked one copy of VNTR B alleles of the GPIbα gene to increased NAION risk and fellow eye involvement.
  • Bilateral NAION cases are rare, and genetic predispositions are under investigation.