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Genome-wide association study of birth weight in sheep
M Ghasemi1, P Zamani1, M Vatankhah2
1Department of Animal Science, Faculty of Agriculture, Bu-Ali Sina University, Hamedan, Iran.
Animal : an International Journal of Animal Bioscience
|January 9, 2019
Summary
This study identified significant genetic markers associated with birth weight in Lori-Bakhtiari sheep. These findings can aid in improving sheep growth and productivity through genetic selection.
Area of Science:
- Animal Genetics
- Quantitative Genetics
- Sheep Breeding
Background:
- Birth weight is a critical early growth trait influencing lamb survival and performance.
- Genetic factors significantly impact birth weight, making it a target for selective breeding.
Purpose of the Study:
- To conduct a genome-wide association study (GWAS) for birth weight in meat-type sheep.
- To identify single-nucleotide polymorphisms (SNPs) associated with estimated breeding values (EBVs) for birth weight.
Main Methods:
- Genotyping of 130 Lori-Bakhtiari sheep using the Illumina Ovine SNP50 Bead Chip.
- Analysis of 41,323 SNPs using Plink 1.90 software.
- Genome-wide association analysis utilizing unadjusted and Bonferroni-adjusted P-values.
Main Results:
- Seven SNPs on chromosomes 1, 16, 19, and 22 showed genome-wide associations (P <10-6).
- Three significant SNPs on chromosome 1 were identified after Bonferroni correction (P <0.05), explaining 0.8% of genetic variation.
- Candidate genes including RAB6B, Tf, and GIGYF2 were located near significant SNPs on chromosome 1.
Conclusions:
- Identified significant SNPs and candidate genes associated with birth weight in sheep.
- Results provide a basis for utilizing genetic information to enhance sheep productivity.
- Future research can focus on these candidate genes for marker-assisted selection in sheep breeding programs.
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