Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Combating severe malaria in African children.

J G Breman, C C Campbell

    Bulletin of the World Health Organization
    |January 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Therapeutic effect of nystatin (fungicidin) in mice experimentally infected with Histoplasma capsulatum.

    Antibiotics & chemotherapy (Northfield, Ill.)·2014
    Same author

    Use of Francis' glucose cystine blood agar in the isolation and cultivation of Sporotrichum schenckii.

    Journal of bacteriology·2010
    Same author

    Social and behavioural baseline for guiding implementation of an efficacy trial of insecticide impregnated bed nets for malaria control at nsukka, Nigeria.

    International quarterly of community health education·2010
    Same author

    Reverting Histoplasma capsulatum to the yeast phase.

    Journal of bacteriology·2010
    Same author

    Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2004
    Same author

    Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae.

    Journal of immunology (Baltimore, Md. : 1950)·2001

    The Africa Child Survival Initiative-Combatting Childhood Communicable Diseases (CCCD) project improved malaria control in 13 African nations. It integrated malaria management into primary healthcare, enhancing treatment and prevention strategies for children and pregnant women.

    Area of Science:

    • Global Health
    • Infectious Diseases
    • Public Health Interventions

    Background:

    • The Africa Child Survival Initiative-Combatting Childhood Communicable Diseases (CCCD) project, established in 1982, operates in 13 African countries, with 12 being malaria-endemic.
    • The project aims to reduce childhood mortality from malaria, diarrhea, and vaccine-preventable diseases.
    • Malaria control strategies focus on drug use (primarily chloroquine) for children under five and chemoprophylaxis for pregnant women, aligning with WHO recommendations.

    Purpose of the Study:

    • To assess the sensitivity of Plasmodium falciparum to chloroquine in children across CCCD countries.
    • To evaluate current malaria treatment practices and identify areas for improvement.
    • To strengthen malaria control units and integrate interventions into primary healthcare.

    Related Experiment Videos

    Main Methods:

    • Drug sensitivity surveillance of Plasmodium falciparum to chloroquine was conducted in 9 of the 13 CCCD countries.
    • Baseline surveys were performed in 6 countries to document existing treatment practices.
    • The establishment and development of malaria control units and national malaria control plans were tracked.

    Main Results:

    • In areas with chloroquine-resistant P. falciparum, chloroquine treatment still reduced fever and parasite density in children, preventing severe illness.
    • Baseline surveys revealed varied treatment practices, including inconsistent dosing and overuse of injections.
    • Research into alternative drug treatments for pregnant women was initiated due to low chemoprophylaxis uptake.
    • Malaria control units increased from 4 to 11 in malarious countries, with integrated national malaria control plans developed.

    Conclusions:

    • The CCCD project has successfully enhanced malaria control infrastructure and strategies in participating African nations.
    • Integration of malaria control into primary healthcare and standardized treatment plans have been achieved.
    • Despite challenges like drug resistance and varied practices, the initiative demonstrates progress in reducing malaria's impact on child survival.