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Updated: Jan 31, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
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Glucose-Regulated TET2 Activity Links Cancer to Diabetes

Hari R Singh1, Stefan H Stricker2

  • 1Physics Department E14, Technical University Munich, 85748 Garching, Germany.

Trends in Cancer
|January 9, 2019
PubMed
Summary

Diabetes increases cancer risk. A new study reveals high glucose destabilizes TET2, a DNA repair enzyme, promoting cancer via an AMPK-dependent pathway.

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