Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.6K
The Thyroid Gland01:23

The Thyroid Gland

7.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.6K
Coronary Circulation01:21

Coronary Circulation

7.2K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.2K
Fetal Circulation01:14

Fetal Circulation

2.9K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
2.9K
Overview of Pulmonary Circulation01:19

Overview of Pulmonary Circulation

3.1K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
3.1K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Utility of Single Ventricular Stroke Work Index for Predicting Prognosis in Patients with Functional Single Ventricle.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Delayed onset of aortic regurgitation after transcatheter closure of atrial septal defect: variable impact of the device on the aortic valve.

Cardiology in the young·2026
Same author

Dominance of Enterobacter spp. in Asymptomatic Sweet Potato Tubers Grown in Foot Rot-infested Fields.

Microbes and environments·2026
Same author

Reversible Lesions of the Genu of the Corpus Callosum and White Matter Detected by MRI in a Neonate With Apnea: A Case Report.

Cureus·2026
Same author

Developmental Regression of Motor Ability in the Patient With Interruption of the Aortic Arch: Juvenile Idiopathic Arthritis Associated With Deletion of 22q11.2 Syndrome.

Cureus·2026
Same author

Perioperative biventricular function in congenital diaphragmatic hernia: a three-dimensional echocardiographic study.

Pediatric research·2026

Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

773

Thyroid Function in Patients With a Fontan Circulation.

Seiko Kuwata1, Manabu Takanashi1, Megumi Hashimoto1

  • 1Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

The American Journal of Cardiology
|January 9, 2019
PubMed
Summary

Thyroid dysfunction is common in Fontan patients and linked to poor heart function. Monitoring thyroid health after Fontan surgery is crucial for better cardiac output and ventricular function.

More Related Videos

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
04:42

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery

Published on: February 17, 2023

1.8K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.3K

Related Experiment Videos

Last Updated: Jan 31, 2026

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

773
A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
04:42

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery

Published on: February 17, 2023

1.8K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.3K

Area of Science:

  • Cardiology
  • Endocrinology
  • Pediatric Surgery

Background:

  • The Fontan operation is a palliative procedure for complex congenital heart defects.
  • Altered hemodynamics and venous congestion are known complications post-Fontan surgery.
  • The impact of thyroid function on post-Fontan hemodynamics remains under-investigated.

Purpose of the Study:

  • To investigate the hypothesis that impaired thyroid function contributes to altered hemodynamics in patients following a Fontan operation.
  • To identify the prevalence of thyroid dysfunction in this patient population.
  • To explore the relationship between thyroid function and hemodynamic parameters.

Main Methods:

  • Cardiac catheterization and thyroid function blood tests were conducted in 37 post-Fontan patients.
  • Thyroid-stimulating hormone (TSH), thyroxine, and free triiodothyronine levels were measured.
  • Correlation analyses were performed between thyroid hormones and hemodynamic parameters like central venous pressure and cardiac index.

Main Results:

  • Subclinical thyroid dysfunction (elevated TSH) was observed in 33% of patients.
  • TSH levels significantly correlated with central venous pressure (R²=0.3).
  • Patients with subclinical hypothyroidism exhibited higher liver congestion markers (γ-glutamyltransferase) and lower free triiodothyronine levels, which correlated negatively with relaxation time constant and brain natriuretic hormone, and positively with cardiac index.

Conclusions:

  • Venous congestion following Fontan surgery may lead to thyroid dysfunction.
  • This thyroid dysfunction can negatively impact ventricular function and cardiac output.
  • Routine monitoring of thyroid function is recommended for patients after Fontan surgery.