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Assaying for Inorganic Polyphosphate in Bacteria
Published on: January 21, 2019
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Role of Polyphosphate in Amyloidogenic Processes
Justine Lempart1, Ursula Jakob1
1Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109.
Cold Spring Harbor Perspectives in Biology
|January 9, 2019
Summary
Polyphosphate (polyP) stabilizes protein folding intermediates, unexpectedly influencing amyloid formation. This discovery suggests polyP
Area of Science:
- Biochemistry
- Molecular Biology
- Neuroscience
Background:
- Polyphosphate (polyP) is a simple polyanion involved in diverse cellular processes.
- Previously unknown role of polyP in stabilizing beta-sheet protein-folding intermediates discovered.
- This finding links polyP to amyloidogenic processes and neurodegenerative diseases.
Purpose of the Study:
- Investigate polyP's effects on amyloidogenic processes.
- Explore the novel concept of polyP's role in neurodegenerative diseases.
- Summarize recent findings on polyP's influence on amyloid formation and toxicity.
Main Methods:
- Literature review of recent experimental results.
- Analysis of polyP's distribution, levels, and roles in the mammalian brain.
- Discussion of potential mechanisms of polyP's neuroprotective effects.
Main Results:
- Polyphosphate (polyP) accelerates amyloid fiber formation.
- PolyP alters the morphology of amyloid fibers.
- PolyP demonstrates protective effects against amyloid toxicity in cellular models.
Conclusions:
- PolyP acts as a physiological modifier influencing amyloidogenesis.
- PolyP may play a significant role in the pathogenesis or progression of neurodegenerative diseases.
- Further research into polyP's mechanisms could reveal therapeutic strategies for amyloid-related disorders.
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