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Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
Published on: September 26, 2012
Influenza Pathogenesis: The Effect of Host Factors on Severity of Disease
Anshu P Gounder1,2, Adrianus C M Boon3,2,4
1Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Abstract:
Influenza viruses continue to be a major global health threat. Severity and clinical outcome of influenza disease is determined by both viral and host factors. Viral factors have long been the subject of intense research and many molecular determinants have been identified. However, research into the host factors that protect or predispose to severe and fatal influenza A virus infections is lagging. The goal of this review is to highlight the recent insights into host determinants of influenza pathogenesis.
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