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Updated: Jan 31, 2026
06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
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Concomitant association of giant cell arteritis and malignancy: a multicenter retrospective case-control study
S Deshayes1, E Liozon2, N Chanson3
1Department of Internal Medicine and Clinical Immunology, Normandie Univ, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000, Caen, France.
Clinical Rheumatology
|January 9, 2019
Summary
Giant cell arteritis (GCA) patients with cancer showed no specific malignancy type. However, male GCA patients with altered general state and polymyalgia rheumatica may have higher rates of concurrent malignancies.
Area of Science:
- Rheumatology
- Oncology
- Internal Medicine
Background:
- Giant cell arteritis (GCA) is a large vessel vasculitis with potential associations with malignancy.
- Previous studies suggest an elevated risk of certain cancers in GCA patients.
Purpose of the Study:
- To investigate the clinical characteristics and outcomes of GCA patients diagnosed with concomitant malignancy.
- To compare these patients with a control group of GCA patients without malignancy.
Main Methods:
- Retrospective study including GCA patients with a malignancy diagnosis within 12 months of each other.
- Comparison with an age-matched control group (3:1 ratio) from a multicenter GCA cohort.
Main Results:
- 49 GCA patients with malignancy were analyzed (median age 76).
- Malignancies included 67% solid neoplasms and 33% hematologic disorders; no specific type predominated.
- GCA patients with malignancy were more frequently male, had an altered general state, and presented with polymyalgia rheumatica compared to controls.
Conclusions:
- No particular malignancy type is over-represented in GCA patients.
- Early malignancy detection may occur during GCA follow-up.
- Male GCA patients with constitutional symptoms and polymyalgia rheumatica warrant closer monitoring for potential concurrent malignancies.
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