Related Experiment Video
Updated: Jan 31, 2026
09:35
Preparation and Evaluation of Hybrid Composites of Chemical Fuel and Multi-walled Carbon Nanotubes in the Study of Thermopower Waves
Published on: April 10, 2015
9.2K
Paclitaxel Encapsulation into Dual-Functionalized Multi-Walled Carbon Nanotubes
Vishakha Rathod1, Rahul Tripathi2, Parth Joshi3
1Maliba Pharmacy College, Uka Tarsadia University, Gopal-Vidyanagar Campus, Surat, 394350, India.
AAPS Pharmscitech
|January 9, 2019
Summary
Researchers synthesized and functionalized multi-walled carbon nanotubes (CNTs) for drug delivery. Functionalized CNTs efficiently encapsulated the anti-cancer drug paclitaxel (PLX) via π-π stacking, enhancing water dispersibility.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Carbon nanotubes (CNTs) offer unique properties for biomedical applications.
- Drug delivery systems require efficient loading and targeted delivery mechanisms.
- Functionalization of CNTs can improve their solubility and interaction with biological targets.
Purpose of the Study:
- To synthesize and characterize dual-functionalized multi-walled carbon nanotubes (CNTs).
- To investigate the encapsulation of the anti-cancer drug paclitaxel (PLX) within functionalized CNTs.
- To assess the impact of functionalization on CNT dispersibility and drug loading.
Main Methods:
- Catalytic chemical vapor deposition (CCVD) for CNT synthesis.
- Transmission electron microscopy (TEM), EDX, FT-IR, and Raman spectroscopy for characterization.
- Dual-functionalization of CNTs with ethylenediamine and phenylboronic acid groups.
- Non-covalent drug loading via π-π stacking.
Main Results:
- Synthesized multi-walled CNTs with an average diameter of 16.5 nm.
- Confirmed dual-functionalization and enhanced water dispersibility of CNTs.
- Achieved high loading of paclitaxel (PLX) into functionalized CNTs, evidenced by Raman spectral shifts.
- Demonstrated successful encapsulation through non-covalent π-π stacking.
Conclusions:
- Dual-functionalized CNTs provide an effective platform for high-capacity, non-covalent loading of paclitaxel.
- Enhanced dispersibility and drug loading capabilities of functionalized CNTs show promise for drug delivery applications.
- Future work will explore CNT interactions with biological targets for cancer therapy.
More Related Videos
09:12Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
Published on: June 1, 2016
9.5K
11:19Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
Published on: May 10, 2018
10.7K
Related Concept Videos
02:43Plant Cell Wall
60.3K
The plant cell wall gives plant cells shape, support, and protection. As a cell matures, its cell wall specializes according to the cell type. For example, the parenchyma cells of leaves possess only a thin, primary cell wall.
60.3K
01:14The Carbon Cycle
43.7K
Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among living organisms, and one in which carbon is cycled over long periods of time through fossilized organic remains, weathering of rocks, and volcanic activity. Human activities, including increased agricultural practices and the burning of fossil fuels, has greatly affected the balance of the natural carbon cycle.
43.7K
01:12Carbon Skeletons
115.0K
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
115.0K
01:24Carbonation Shrinkage
477
Atmospheric CO2 penetrates the concrete's pores and, in the presence of moisture, forms carbonic acid, which then reacts with calcium hydroxide in the hydrated cement, forming calcium carbonate. This process reduces the concrete's volume and is termed carbonation shrinkage.
The concrete's permeability is slightly reduced as calcium carbonate produced during the reaction fills its pores. Furthermore, its strength is slightly enhanced as the water released during the reaction...
The concrete's permeability is slightly reduced as calcium carbonate produced during the reaction fills its pores. Furthermore, its strength is slightly enhanced as the water released during the reaction...
477
02:45Functional Groups
88.5K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
88.5K
01:18Composite Masonry Walls
1.7K
Composite masonry walls combine multiple wythes of the same or different masonry materials to create a unified structure. These walls feature wythes that are bonded together either through mortar-filled collar joints, grouted spaces, or more commonly, with rigid metal ties and reinforcements, with the use of masonry header units being rare. Metal ties are preferred because they effectively minimize water penetration, as these walls primarily absorb moisture and then release it into the...
1.7K