Targeting Angiogenesis in Colorectal Carcinoma

Anthony Lopez1,2, Kazuto Harada1, Maria Vasilakopoulou1

  • 1Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Drugs
|January 9, 2019
PubMed

Insights

Anti-angiogenic therapies, including bevacizumab, have improved colorectal cancer outcomes. Further research is needed to optimize treatment sequencing and identify new, cost-effective anti-angiogenic drugs with predictive biomarkers.

Area of Science:

  • Oncology
  • Vascular Biology

Background:

  • Neo-angiogenesis is crucial in colorectal cancer, driven by vascular endothelial growth factor (VEGF) signaling pathways.
  • Anti-angiogenic therapies have significantly improved colorectal cancer prognosis over the last 15 years.
  • Bevacizumab and other agents like ramucirumab and aflibercept demonstrate the success of continuous anti-angiogenic blockade.

Purpose of the Study:

  • To review the role of anti-angiogenic therapies in colorectal cancer.
  • To discuss the efficacy and sequencing of current anti-angiogenic agents.
  • To highlight the need for future research in biomarker discovery and novel drug development.

Main Methods:

  • Review of clinical trial data and literature on anti-angiogenic therapies in colorectal cancer.
  • Analysis of the efficacy and sequencing strategies of approved anti-angiogenic agents.
  • Discussion of emerging therapies, including tyrosine kinase inhibitors and biosimilars.

Main Results:

  • Bevacizumab has shown efficacy in various settings (first-line, second-line, maintenance).
  • Sequential use of anti-angiogenic drugs (e.g., ramucirumab, aflibercept) after bevacizumab failure is established.
  • New oral tyrosine kinase inhibitors show modest efficacy in late-stage trials.

Conclusions:

  • Optimizing therapeutic sequencing of anti-angiogenic agents requires well-designed prospective randomized trials.
  • The role of biosimilars in colorectal cancer treatment is currently undefined.
  • Further research should focus on identifying predictive biomarkers and developing cost-efficient, clinically meaningful anti-angiogenic drugs.

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