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No Increased Risks Associated with Propranolol Treatment for Infantile Hemangioma in Preterm Infants were Identified

Li Li1, Li Wei1, Zi-Gang Xu1

  • 1Department of Dermatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, No. 56 Nanlishi Road, Beijing, 100045, China.

American Journal of Clinical Dermatology
|January 9, 2019
PubMed

Insights

Propranolol treatment for infantile hemangioma (IH) in preterm infants showed no increased risks of adverse effects or growth impairment compared to term infants up to age three years.

Area of Science:

  • Pediatric pharmacology
  • Neonatology
  • Dermatology

Background:

  • Infantile hemangioma (IH) treatment with propranolol raises concerns for preterm infants.
  • Preterm infants' immature development may increase risks of adverse effects and growth impairment.

Purpose of the Study:

  • To compare the incidence of long-term adverse effects and growth impairment in preterm versus term infants treated for IH with propranolol.
  • To assess the safety and efficacy of propranolol in preterm infants with IH.

Main Methods:

  • Retrospective analysis of clinical data from 55 preterm and 180 term infants with IH.
  • All infants received oral propranolol for 6 months.
  • Comparison of adverse effect incidence and growth parameters (height, weight, head circumference) up to age 3 years.

Main Results:

  • No significant differences in general characteristics or adverse effect incidence between preterm and term infants.
  • Preterm infants' growth (height, weight, head circumference) up to age 3 years did not differ from normal references.
  • Term infants showed significantly higher weight and head circumference at 1 year compared to normal references.

Conclusions:

  • Six-month propranolol treatment for IH did not elevate risks for adverse effects or growth impairment in preterm infants compared to term infants.
  • Propranolol appears to be a safe treatment option for infantile hemangioma in preterm infants up to age three years.
Abstract

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