Related Experiment Video
Updated: Jan 31, 2026
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Value of CT iterative metal artifact reduction in PET/CT-clinical evaluation in 100 patients
Christian Philipp Reinert1, Christian la Fougère2, Konstantin Nikolaou1
11 Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen , Tuebingen , Germany.
Objective::
To assess the technical feasibility and diagnostic benefit of CT iterative metal artifact reduction (iMAR) in patients with metal implants undergoing positron emission tomography (PET/CT.
Methods::
PET/CTs of 100 patients with metal implants in different anatomical localization were retrospectively analyzed. CT data were reconstructed with iMAR and without iMAR (noMAR) and used in comparison for PET attenuation correction, generating iMAR-corrected and noMAR PET data. The effect of iMAR on quantitative CT and PET analysis was assessed by measurements of Hounsfield units (HUs) and standard uptake values (SUV) in predefined anatomical structures and pathological lesions in the vicinity of metal implants. Diagnostic confidence for lesion delineation was assessed using a 3-point scale.
Results::
For artifact-affected structures, mean HU of iMAR corrected CT significantly differed compared to noMAR CT and standard deviations were significantly lower [e.g. M. masseter: 71.01 ± 22.34 HU (iMAR) vs 98.89 ± 92.18 HU (noMAR), p < .01]. SUVs did not significantly differ in artifact-affected structures [e.g. M. masseter: SUVmean 0.96 ± 0.54 (iMAR) vs 0.97 ± 0.55 (noMAR); p > .89] and pathological findings [SUVmean 10.78 (iMAR) vs 10.81 (noMAR); p > .98] between iMAR and noMAR PET. Qualitatively, delineation was significantly improved in iMAR corrected CT for the interpretation of anatomical and pathological structures [e.g. score of pathologic lesions: 2.80 (iMAR) vs 2.31 (noMAR); p < .01].
Conclusion::
The use of iMAR in PET/CT significantly improves delineation of anatomical and pathological structures in the vicinity of metal implants in CT. PET quantification and PET image quality are not significantly affected by the use of iMAR-based attenuation correction independent of the presence of metal implants.
Advances In Knowledge::
IMAR is a feasible algorithm in PET/CT improving CT image quality in the vicinity of metal implants without affecting PET quantification and can therefore be implemented in the clinical routine.
More Related Videos
08:55A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Related Concept Videos
01:30Radiological Investigation I: X-ray and CT
01:14Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
01:28Imaging Studies for Cardiovascular System V: CT
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
03:11Oxidation-Reduction Reactions
02:51Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...