Solanrubiellin A, a hydroanthraquinone dimer with antibacterial and cytotoxic activity from Solanum lyratum
Hui Chen1,2, Kun Du1,2, Yan-Jun Sun1,2
1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Abstract:
A new hydroanthraquinone dimer derivative, solanrubiellin A, was isolated from the whole plants of Solanum lyratum. The structure of 1 was established through extensive NMR spectroscopy analysis, and the absolute configuration was elucidated by comparison of its experimental and calculated ECD spectra. Compound 1 showed antibacterial activity with MIC values of 2-10 µM against several Gram-positive bacteria. Compound 1 also demonstrated cytotoxic activity against human A549, HT-29 and HL-60 cell lines with IC50 values ranging from 2.06 to 9.35 µM.
More Related Videos
Related Concept Videos
Eukaryotic Transcription Activators
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Co-activators and Co-repressors
tRNA Activation
Activation Energy
Secondary Active Transport


