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Updated: Jan 31, 2026

Methylated DNA Immunoprecipitation
Published on: January 2, 2009
Measured maternal prepregnancy anthropometry and newborn DNA methylation
Edwina H Yeung1, Weihua Guan2, Sunni L Mumford1
1Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, 6710B Rockledge Drive 7004, Bethesda, MD 20817, USA.
Aim:
We examined maternal prepregnancy anthropometry and cord blood DNA methylation.
Methods:
Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons.
Results:
Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10-8). A suggestive association (p < 10-6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults.
Conclusion:
While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.
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