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Updated: Jan 31, 2026

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
Electrospun Nanofibers with Core-Shell Structure for Treatment of Bladder Regeneration
Chunxiang Feng1,2, Chang Liu1, Shiliang Liu1
1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Impact Statement:
The extracellular matrix (ECM)-inspired electrospinning scaffolds have a good cytocompatibility. Hyaluronic acid (HA) is one of the main components in the bladder ECM, but it is hard to be made by electrospinning alone. In this study, it is shown that coaxial electrospinning can fabricate poly(l-lactide)/poly(e-caprolactone) (PLCL)/HA nanofibers with the core-shell structure. The HA coating nanofibers have more hydrophilicity, which can promote cell proliferation and migration by filopodial outgrowth. We also fabricated domed PLCL/HA nanofiber scaffolds used in bladder regeneration by improving bladder capacity and facilitating smooth muscle proliferation.
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