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Related Experiment Video

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How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index

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Dynamic Communications Between GABA_A Switch, Local Connectivity, and Synapses During Cortical Development: A

Radwa Khalil¹, Ahmed A Karim^1,2, Eman Khedr³

¹Department of Psychology and Methods, Jacobs University Bremen, Bremen, Germany.

Frontiers in Cellular Neuroscience

|January 9, 2019

Summary

Dynamical synapses and short-term plasticity modulate neural network activity during cortical development. Their effects depend on the GABA_A physiological state, impacting firing rates and network scenarios.

Keywords:

GABAA signaling STD STF cortical development dynamical synapses firing rate activity in vitro local connectivity

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Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

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Published on: November 1, 2019

Area of Science:

Computational Neuroscience
Neurodevelopment
Neural Network Modeling

Background:

Cortical development involves complex regulation of neural network activity.
GABA_A reversal potential shifts during early development, influencing neuronal excitability.
Previous models have not integrated these factors into a unified framework.

Purpose of the Study:

To develop an integrative computational model simulating factors in cortical development.
To investigate the combined effects of GABA_A state, connectivity, and synaptic plasticity on neural firing activity.
To explore clinical implications for neurological and psychiatric disorders.

Main Methods:

Developed a Spiking Neural Network model with biophysical parameters for lateral and local connectivity.
Simulated immature and mature cortical network conditions.
Implemented two forms of short-term synaptic plasticity (STP) with varying time constants.

Main Results:

Dynamical synapses significantly modulate neural network firing activity, dependent on the GABA_A physiological state.
Short-term synaptic plasticity mechanisms exhibit differential effects across network scenarios.
The interplay between GABA_A state and STP is crucial for shaping neural activity during development.

Conclusions:

The study provides the first integrative computational model of key factors in cortical development.
Findings highlight the critical role of GABAergic signaling and synaptic plasticity in neural network regulation.
Results offer insights into pathological alterations in neurological and psychiatric disorders.