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Plasma D-Dimer Concentrations and Risk of Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Zhike Zhou1, Yifan Liang2, Xiaoqian Zhang2

  • 1Department of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang, China.

Frontiers in Neurology
|January 9, 2019
PubMed

Insights

Higher plasma d-dimer levels are associated with an increased risk of intracerebral hemorrhage (ICH). This finding suggests d-dimer may be a useful biomarker for ICH, particularly in Asia and Europe.

Area of Science:

  • Neurology
  • Hematology
  • Biomarker Discovery

Background:

  • Intracerebral hemorrhage (ICH) is a critical neurological condition.
  • Identifying reliable biomarkers for ICH risk is essential for early detection and management.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between plasma d-dimer levels and intracerebral hemorrhage (ICH).

Main Methods:

  • Comprehensive literature search of Embase, Pubmed, and Web of Science databases.
  • Inclusion of 13 studies with 891 ICH patients and 1,573 healthy controls.
  • Statistical analysis using standard mean difference (SMD) with 95% confidence intervals (CI).

Main Results:

  • Elevated plasma d-dimer levels were significantly higher in ICH patients compared to healthy controls (95% CI = 0.98-2.00, p < 0.001).
  • Subgroup analyses by continent revealed this association in Asia and Europe, but not in America.
  • No significant impact of sample size or age on the observed d-dimer levels in ICH patients.

Conclusions:

  • High plasma d-dimer levels are strongly associated with an increased risk of intracerebral hemorrhage.
  • Plasma d-dimer shows potential as a predictive biomarker for ICH, especially in Asian and European populations.
  • Geographical variations may influence the utility of d-dimer as an ICH biomarker.

Keywords:
arteriovenous malformationintracerebral hemorrhagemeta-analysisplasma d-dimerrisk factor

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