Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serotonin in involuntary movement disorders.

R Sandyk1, H Fisher

  • 1Department of Neurology, University of Arizona, Tucson 85724.

The International Journal of Neuroscience
|October 1, 1988
PubMed
Summary

Serotonin pathways in the central nervous system (CNS) are crucial for motor control. This review highlights defective serotonin function in human movement disorders and discusses treatments using serotonergic drugs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How applicable is the TNM 8 staging for human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma (OPSCC) to a UK population of 106 patients? : A cohort comparison of the TNM 7 and TNM8 staging systems for HPV positive oropharyngeal cancer in a UK population.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2020
Same author

Prescribing in pregnancy for women with diabetes: use of potential teratogenic drugs and contraception.

Diabetic medicine : a journal of the British Diabetic Association·2012
Same author

Assessment and management of the violent patient.

Canadian family physician Medecin de famille canadien·2011
Same author

Association of Xanthomonas phaseoli and the common bean-mosaic virus, Marmor phaseoli; the effect of varying amounts of nitrogen on pathogenicity.

Phytopathology·2010
Same author

Ethnicity, social disadvantage and psychotic-like experiences in a healthy population based sample.

Acta psychiatrica Scandinavica·2008
Same author

Self-reported childhood trauma correlates with schizotypal measures in schizophrenia but not bipolar pedigrees.

Psychological medicine·2008

Area of Science:

  • Neuroscience
  • Neurology
  • Pharmacology

Background:

  • Recent studies highlight the role of central nervous system (CNS) serotonergic pathways in motor behavior.
  • Serotonergic pathways are implicated in the pathophysiology of human involuntary movement disorders.
  • Significant serotonergic innervation of the striatum and substantia nigra suggests a close interaction with the dopamine system.

Purpose of the Study:

  • To summarize evidence linking defective serotonergic functions to human movement disorders.
  • To discuss the management of these disorders using serotonergic drugs.

Main Methods:

  • Review of existing scientific literature and studies.
  • Analysis of evidence for serotonergic dysfunction in movement disorders.
  • Evaluation of the efficacy of serotonergic drugs in treatment.

Main Results:

  • Evidence demonstrates impaired serotonergic function in various human movement disorders.
  • Serotonergic drugs show potential in managing these conditions.

Conclusions:

  • Serotonergic system dysfunction is a key factor in several human movement disorders.
  • Pharmacological modulation of the serotonergic system offers a viable therapeutic strategy.

Related Experiment Videos