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Related Concept Videos

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Modeling Inflammation in Autism Spectrum Disorders Using Stem Cells.

Beatriz C Freitas1, Arianna Mei2, Ana Paula D Mendes2

  • 1Laboratory of Disease Modeling, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Frontiers in Pediatrics
|January 9, 2019
PubMed
Summary

Autism Spectrum Disorder (ASD) incidence is rising. This review explores how neuroinflammation contributes to ASD and examines stem cell models for potential therapies.

Keywords:
autism spectrum disorder (ASD)disease modelinginduced pluripotent stem (iPS) cellsneurodevelopmental disordersneuroinflammation

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Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Biology

Background:

  • Autism Spectrum Disorder (ASD) incidence is increasing, affecting 1 in 59 children in North America.
  • Neuroinflammation and immune system dysfunction are linked to ASD development.
  • Multiple cell types are involved in triggering and sustaining these inflammatory processes.

Purpose of the Study:

  • To review the contribution of neuroinflammation to autistic features.
  • To discuss potential therapeutic strategies for ASD.
  • To highlight stem cell modeling as a tool for studying neuroinflammation in ASD.

Main Methods:

  • Review of current scientific literature on neuroinflammation and ASD.
  • Emphasis on induced pluripotent stem cell (iPSC) technology for disease modeling.
  • Analysis of molecular pathways and cell types involved in neuroinflammation.

Main Results:

  • Neuroinflammation plays a significant role in the development of ASD.
  • Stem cell models provide a platform to study complex polygenic disorders like ASD.
  • Various cell types and molecular pathways contribute to neuroinflammation in ASD.

Conclusions:

  • Understanding neuroinflammation is crucial for developing effective ASD therapies.
  • iPSC technology offers a promising avenue for investigating ASD mechanisms.
  • Targeting neuroinflammation presents a potential therapeutic approach for ASD.