Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Environment-genetic influences on immunocompetence.

W B Gross1, P B Siegel

  • 1Virginia Polytechnic Institute, Blacksburg.

Journal of Animal Science
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research Note: Phenotypic trends for the multigenerational advanced intercross of the Virginia body weight lines of chickens.

Poultry science·2024
Same author

Low-coverage sequencing in a deep intercross of the Virginia body weight lines provides insight to the polygenic genetic architecture of growth: novel loci revealed by increased power and improved genome-coverage.

Poultry science·2023
Same author

Population dynamics of a long-term selection experiment in White Plymouth Rock chickens selected for low or high body weight.

Poultry science·2023
Same author

Epigenetic modifiers identified as regulators of food intake in a unique hypophagic chicken model.

Animal : an international journal of animal bioscience·2022
Same author

A genomic inference of the White Plymouth Rock genealogy.

Poultry science·2019
Same author

Long-term selection of chickens for body weight alters muscle satellite cell behaviors.

Poultry science·2018

Animal immune responses are dynamic, influenced by genetics and environment. Stress impacts immunity, affecting antibody production and cell-mediated defenses, but can be mitigated.

Area of Science:

  • Immunology
  • Animal Science
  • Environmental Science

Background:

  • Animal immune responses are constantly adapting to environmental cues.
  • Genetic background and lifelong environmental exposures significantly shape an animal's immunological responsiveness.
  • Immunocompetence is influenced by factors like age of onset, antigen responsiveness, antibody characteristics, and response persistence.

Purpose of the Study:

  • To explore the intricate relationship between genetic factors, environmental influences, and immunological responses in animals.
  • To investigate how resource allocation affects immune defense mechanisms.
  • To understand the impact of environmental stress on various aspects of the immune system.

Main Methods:

  • Analysis of how genetic background influences immunocompetence parameters.

Related Experiment Videos

  • Observation of resource trade-offs between immune defense and other physiological functions (e.g., growth, feed efficiency).
  • Assessment of the effects of environmental stress on antibody production and cell-mediated immunity.

    • Main Results:

    • Chickens with high antibody responses exhibit reduced growth and feed efficiency, indicating resource allocation trade-offs.
    • Selection for high antibody titers can lead to decreased macrophage effectiveness.
    • Stress during antigen exposure reduces antibody response; stress after response initiation has minimal effect.
    • Stress enhances cell-mediated immunity sensitization but reduces its effectiveness.
    • Short-term stressors like weaning cause a temporary dip in immunocompetence.

    Conclusions:

    • Animal immunity is a complex system where genetic and environmental factors interact dynamically.
    • Immune defense involves resource allocation, potentially compromising other functions.
    • Environmental stressors significantly modulate immune responses, affecting both innate and adaptive immunity.
    • Strategies like adrenal blocking or socialization can mitigate stress-induced reductions in immunocompetence.