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Updated: Jan 31, 2026

Controllable Ion Channel Expression through Inducible Transient Transfection
Published on: February 17, 2017
Daratumumab-induced transient myopic shift
Maria A Mavrommatis1, Hoon Jung2, Ajai Chari3
1Icahn School of Medicine at Mount Sinai, 1468 Madison Ave, New York, NY, 10029, USA.
Purpose:
To describe an unprecedented case of transient myopic shift induced by a chemotherapeutic agent, daratumumab.
Observations:
A 43-year-old emmetropic female with multiple myeloma experienced sudden onset of myopic shift during her first intravenous dose of daratumumab, an increasingly common FDA-approved chemotherapeutic agent. Her myopia was corrected with -4D lenses in both eyes, and the patient reports cessation of symptoms and disuse of lenses after two days.
Conclusions And Importance:
A number of medications have been documented to induce transitory myopic shift, and this report now includes daratumumab among such agents. Further clinical findings regarding the mechanism and frequency of daratumumab-induced myopic shift are needed to further develop our understanding of its tangential effect on the eye.
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