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Glycated haemoglobins.

R Flückiger¹, H B Mortensen

¹Department of Research and Internal Medicine, University Clinics Basel, Switzerland.

Journal of Chromatography

|July 29, 1988

Summary

Glycated haemoglobin (HbA1c) testing is crucial for managing diabetes mellitus. Advances in HbA1c measurement have improved glycaemia assessment and revealed new insights into hemoglobin modifications and variants.

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Area of Science:

Clinical Chemistry
Endocrinology
Hematology

Background:

The link between elevated glycated haemoglobins and diabetes mellitus is well-established.
Glycated haemoglobin measurement is vital for assessing long-term glycemic control in diabetic patients.
Clinical demand has driven significant methodological advancements in glycated haemoglobin determination.

Purpose of the Study:

To review the evolution and impact of glycated haemoglobin measurement in diabetes care.
To highlight how analytical challenges have spurred fundamental discoveries in hemoglobin biochemistry.
To underscore the role of routine HbA1c testing in identifying novel hemoglobin variants.

Main Methods:

Review of historical and current methodologies for glycated haemoglobin quantification.
Analysis of how technical limitations have informed basic research.
Examination of data from large-scale diabetic patient populations.

Main Results:

Methodological improvements have refined the assessment of long-term glycemia.
Investigation into analytical issues revealed previously unknown in vivo processes, including non-enzymatic glycation at various sites and labile adducts.
Routine glycated haemoglobin screening serves as a broad platform for detecting clinically silent mutant hemoglobins.

Conclusions:

The determination of glycated haemoglobins is indispensable for diabetes management.
Overcoming analytical challenges in glycated haemoglobin measurement has significantly advanced biomedical research.
Routine HbA1c testing plays a dual role in patient care and population-level hemoglobin variant screening.

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