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Related Experiment Videos

Alkaline phosphatase. Laboratory and clinical implications.

W Meyer-Sabellek1, P Sinha, E Köttgen

  • 1Department of Internal Medicine, Universitätsklinikum Steglitz, Free University, Berlin, F.R.G.

Journal of Chromatography
|July 29, 1988
PubMed
Summary

Alkaline phosphatase (ALP) is extensively reviewed, covering its biochemical properties and clinical significance. Analysis of ALP isoforms aids in diagnosing bone diseases and evaluating tumors as potential biomarkers.

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Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Molecular Biology

Background:

  • Alkaline phosphatase (ALP), discovered in 1907, plays crucial roles in various physiological processes.
  • Understanding ALP's biochemical characteristics and clinical implications is vital for disease diagnosis.

Purpose of the Study:

  • To provide a comprehensive review of alkaline phosphatase (ALP).
  • To discuss the biochemical aspects, including membrane anchorage and isoform heterogeneity.
  • To evaluate the clinical significance of ALP analysis in various diseases and as a tumor marker.

Main Methods:

  • Review of biochemical properties, including phosphatidylinositol linkage and molecular mass.
  • Analysis of ALP isoforms using advanced electrophoresis techniques like affinity electrophoresis and isoelectric focusing.

Related Experiment Videos

  • Critical evaluation of clinical data related to ALP in cholestasis, bone diseases, and tumors.

    • Main Results:

    • Detailed examination of ALP's biochemical characteristics, such as its membrane anchorage and heterogeneity.
    • Discussion of advanced methods for separating and analyzing ALP isoforms.
    • Comprehensive overview of ALP's clinical relevance in conditions like cholestasis, bone disorders, and its potential as a tumor marker.

    Conclusions:

    • Alkaline phosphatase (ALP) exhibits complex biochemical properties and significant clinical utility.
    • Advanced analytical techniques enable better characterization of ALP isoforms.
    • ALP analysis is valuable for diagnosing various diseases and holds potential as a tumor marker.