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Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study
Valentina Vozella1, Abdul Basit1, Fabrizio Piras2
1Department of Drug Discovery and Development, Italian Institute of Technology, Genova 16163, Italy.
Aging
|January 9, 2019
Summary
Aging increases circulating ceramide levels, particularly in women. Lower estradiol levels in post-menopausal women may contribute to this rise, as shown by in vitro studies.
Area of Science:
- Biochemistry
- Gerontology
- Endocrinology
Background:
- Circulating ceramide levels are elevated in age-related diseases.
- The impact of aging on plasma ceramide levels requires systematic investigation.
Purpose of the Study:
- To examine the association between age and plasma ceramide levels.
- To investigate the relationship between plasma ceramides, age, and estradiol levels.
Main Methods:
- Quantified plasma ceramides and dihydroceramides in 164 subjects (aged 19-80).
- Utilized multivariable linear regression and correlation analyses.
- Conducted in vitro experiments with human cancer cells and estradiol.
Main Results:
- Age positively correlated with specific ceramides (d18:1/24:0 and d18:1/24:1) in women, and d18:1/24:1 in men.
- Plasma ceramide (d18:1/24:1) negatively correlated with plasma estradiol in women.
- Estradiol treatment reduced ceramide accumulation in vitro.
Conclusions:
- Aging is linked to increased circulating ceramide levels.
- Lower estradiol levels may partially explain elevated ceramides in post-menopausal women.
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