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Updated: Jan 31, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
Magnetofluorescent Nanocomposite Comprised of Carboxymethyl Dextran Coated Superparamagnetic Iron Oxide Nanoparticles
Daewon Han1, Seung-Yun Han2, Nam Seob Lee3
1Department of Cell Biology, Konyang University College of Medicine, Daejeon 302-718, Korea. eodnjs0319@naver.com.
Abstract:
Red emitting europium (III) complexes Eu(TFAAN)₃(P(Oct)₃)₃ (TFAAN = 2-(4,4,4-Trifluoroacetoacetyl)naphthalene, P(Oct)₃ = trioctylphosphine) chelated on carboxymethyl dextran coated superparamagnetic iron oxide nanoparticles (CMD-SPIONs) was synthesized and the step wise synthetic process was reported. All the excitation spectra of distinctive photoluminesces were originated from f-f transition of EuIII with a strong red emission. The emission peaks are due to the hypersensitive transition ⁵D₀→⁷F₂ at 621 nm and ⁵D₀→⁷F₁ at 597 nm, ⁵D₀→⁷F₀ at 584 nm. No significant change in PL properties due to addition of CMD-SPIONs was observed. The cytotoxic effects of different concentrations and incubation times of Eu(TFAAN)₃(P(Oct)₃)₃ chelated CMD-SPIONs were evaluated in HEK293T and HepG2 cells using the WST assay. The results imply that Eu(TFAAN)₃(P(Oct)₃)₃ chelated CMD-SPIONs are not affecting the cell viability without altering the apoptosis and necrosis in the range of 10 to 240 μg/mL concentrations.
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