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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
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Advances in Molecularly Imprinting Technology for Bioanalytical Applications
Runfa Li1, Yonghai Feng2, Guoqing Pan3
1Institute for Advanced Materials, School of Material Science and Engineering, Jiangsu University. blark_lee@sina.com.
Sensors (Basel, Switzerland)
|January 10, 2019
Summary
Molecular imprinting technology (MIT) combined with biosensing creates advanced molecularly imprinted polymer (MIP) bioprobes and biosensors. These artificial receptors offer superior binding affinity and stability for biomolecule and drug detection.
Area of Science:
- Biotechnology and Biomedical Engineering
- Materials Science
- Analytical Chemistry
Background:
- Molecular imprinting technology (MIT) is increasingly integrated with biosensing platforms.
- Molecularly imprinted polymers (MIPs) offer advantages over natural receptors, including enhanced binding affinity and stability in harsh conditions.
- MIPs are emerging as versatile tools for biomolecule and drug detection.
Purpose of the Study:
- To review recent advancements in MIP-based bioprobes and biosensors.
- To focus on MIP applications for detecting biomolecules and drugs.
- To categorize MIP sensors by their sensing methodologies.
Main Methods:
- Categorization of MIP bioprobes and biosensors based on sensing methods: optical, electrochemical, gravimetric, and magnetic.
- Discussion of the working mechanisms for each sensing category.
- Highlighting novel structures, modifiers, and multi-functional MIP designs.
Main Results:
- MIPs provide robust artificial recognition sites for targeted analytes.
- Various sensing platforms (optical, electrochemical, gravimetric, magnetic) demonstrate effective MIP integration.
- Recent developments focus on enhancing MIP properties and creating multi-functional sensing systems.
Conclusions:
- MIP-based bioprobes and biosensors represent a significant advancement in detection technologies.
- The review covers diverse sensing strategies and highlights future directions for interdisciplinary applications.
- Continued innovation in MIP design promises improved performance and broader applicability.
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