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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
Published on: February 27, 2018
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Risk factors for early postoperative cognitive dysfunction after colorectal surgery.
Yuan Zhang1, Hong-Guang Bao2, Yun-Luo Lv1
1Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, China.
BMC Anesthesiology
|January 10, 2019
Summary
Early postoperative cognitive dysfunction (POCD) after colorectal surgery is linked to diabetes history, prolonged fasting, and elevated SIRS scores. Identifying these risk factors aids in preventing POCD in surgical patients.
Area of Science:
- Anesthesiology
- Gastroenterology
- Gerontology
Background:
- Postoperative cognitive dysfunction (POCD) is associated with neurological, inflammatory, and immune system changes.
- Risk factors for POCD in cardiac surgery include advanced age, comorbidities, and prolonged surgery/ICU stay.
- This study investigates risk factors for early POCD specifically after colorectal surgery.
Purpose of the Study:
- To identify key risk factors contributing to the development of early postoperative cognitive dysfunction (POCD) in patients undergoing colorectal surgery.
- To provide data for the development of preventative strategies against POCD in this patient population.
Main Methods:
- Eighty patients undergoing colorectal surgery under general anesthesia were enrolled.
- Neuropsychological tests were administered preoperatively and on postoperative day seven.
- Multivariate logistic regression analysis was employed to determine significant risk factors for POCD.
Main Results:
- Nearly 25% of patients (19 out of 80) were diagnosed with early POCD.
- Significant risk factors identified include a history of diabetes (OR=8.391), fasting for over 3 days post-surgery (OR=5.236), and a Systemic Inflammatory Response Syndrome (SIRS) score >3 on postoperative day two (OR=6.995).
Conclusions:
- Diabetes history, prolonged postoperative fasting, and a high SIRS score on postoperative day two are significant risk factors for early POCD after colorectal surgery.
- These findings highlight modifiable and pre-existing conditions that clinicians should consider when assessing POCD risk.
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