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Effect of cognitive training on episodic memory retrieval in amnestic mild cognitive impairment patients: study

Kan Zhang1, Junyang Wang1, Guoping Peng1

  • 1Department of Neurology, The First Affiliated Hospital of Medical School of Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003, China.

Trials
|January 10, 2019
PubMed
Abstract

Insights

This study investigates if internet-based cognitive control training can improve memory in mild cognitive impairment (MCI) patients. The training showed potential for enhancing episodic memory retrieval in individuals with amnestic MCI.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • Mild cognitive impairment (MCI) represents a transitional phase between normal cognition and dementia.
  • Amnestic MCI (aMCI) patients, characterized by memory deficits, face a high risk of progressing to Alzheimer's disease (AD).
  • Current pharmacological interventions for preventing dementia progression in aMCI are limited, highlighting the need for alternative therapeutic strategies.

Purpose of the Study:

  • To evaluate the efficacy of an Internet-based cognitive control training program in enhancing episodic memory retrieval in aMCI patients.
  • To explore the potential of cognitive control training to improve memory function in aMCI, building on its known effects in healthy older adults.
  • To investigate the neural underpinnings of cognitive control training effects using multi-modal neuroimaging.

Main Methods:

  • A single-center, randomized, double-blind, placebo-controlled study involving 70 aMCI patients.
  • Participants were assigned to either a cognitive control training group or a control group.
  • The intervention consisted of a 12-week, Internet-based program (30 min/day, 5 days/week), with assessments including neuropsychological tests and structural/functional MRI.

Main Results:

  • The study aimed to determine if cognitive control training enhances episodic memory retrieval in aMCI.
  • Neuropsychological assessments and multi-modal MRI were used to measure changes in memory function and neuroplasticity.
  • The primary outcome was the change in episodic memory retrieval function, with secondary outcomes focusing on MRI-based neuroplasticity.

Conclusions:

  • An Internet-based cognitive control training program was employed to assess its impact on episodic memory retrieval in aMCI.
  • The study hypothesizes that cognitive control training can improve memory function in aMCI patients.
  • The combination of neuropsychological testing and multi-modal MRI is expected to provide sensitive measures of training efficacy and reveal underlying neural mechanisms.
Keywords:
Clinical randomized trialCognitive control trainingMRINeural plasticityaMCI

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