Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

First Pass Effect01:12

First Pass Effect

9.3K
Presystemic elimination, or the first-pass effect, is the metabolism of drugs that reduces their effective concentration at the site of action. Apart from the first-pass effect, the systemic bioavailability of the drug is also reduced by other factors, including incomplete absorption or chemical degradation of drugs.
Depending on the route of administration, drugs can be metabolized in the liver, intestine, lungs, and vasculature. Orally administered drugs are first absorbed through the...
9.3K
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.3K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.3K
Partial Fractions01:28

Partial Fractions

217
A partial fraction is a component of a rational expression represented as the sum of simpler fractions. When a rational function is expressed as a ratio of two polynomials, it can often be decomposed into a sum of fractions whose denominators are simpler polynomials, typically linear or irreducible quadratic factors. This process is called partial fraction decomposition, and it is used to simplify complex expressions for integration, solving equations, or analysis.Partial fraction decomposition...
217
Single-pass Transmembrane Proteins01:25

Single-pass Transmembrane Proteins

6.6K
Integral membrane proteins are tightly associated with the cell membrane and play a crucial role in cell communication, signaling, adhesion, and transport of the molecules. Some integral membrane proteins are present only in the membrane monolayer. For example, the enzyme fatty acid amide hydrolase is present in the cytoplasmic side of the membrane monolayer. In contrast, another type of integral membrane protein, also known as a transmembrane protein, spans across the membrane. Transmembrane...
6.6K
Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

8.1K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
8.1K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

801
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
801

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HECTOR: A Trauma Course to Match Our Population.

Irish medical journal·2026
Same author

How can we make postnatal information resources more accessible to women experiencing challenges accessing healthcare? Report of a co-production project.

International journal for equity in health·2025
Same author

The Stable Acute Vertebral (SAVe) compression fracture study.

Irish medical journal·2024
Same author

What makes an athlete? A scoping review: Assessing the use of the word athlete with anterior cruciate ligament rehabilitation review studies. Is there a standard?

Scandinavian journal of medicine & science in sports·2024
Same author

Massive Pericardial Effusion.

Irish medical journal·2022
Same author

Preoperative and intraoperative factors predictive of complications and stricture recurrence following multiple urethroplasty techniques.

BJUI compass·2022

Related Experiment Video

Updated: Jan 31, 2026

A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

22.6K

This too shall pass: Standardized Gastrografin protocol for partial small bowel obstruction.

S Long1, B Emigh1, J S Wolf1

  • 1The University of Texas at Austin, Dell Medical School, Department of Surgery & Perioperative Care, 1313 Red River Street, Austin, TX, 78701, USA.

American Journal of Surgery
|January 10, 2019
PubMed
Summary

A protocol using Gastrografin for partial small bowel obstruction management significantly reduced surgery rates and hospital stays in a community setting. This approach proved effective outside of clinical trials.

More Related Videos

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

16.5K
An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

850

Related Experiment Videos

Last Updated: Jan 31, 2026

A Mouse Model of Intestinal Partial Obstruction
07:33

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

22.6K
Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

16.5K
An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
06:37

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

850

Area of Science:

  • Gastroenterology
  • Surgical Management
  • Radiology

Background:

  • Partial small bowel obstruction is a common surgical admission with varied management strategies.
  • Diatrizoate (Gastrografin) shows promise as a diagnostic and therapeutic agent, potentially reducing surgical intervention.
  • Limited data exists on Gastrografin's use in community healthcare settings.

Purpose of the Study:

  • To evaluate the effectiveness of a standardized Gastrografin administration protocol for partial small bowel obstruction.
  • To determine if this protocol reduces surgical intervention and length of hospital stay in a community setting.
  • To assess Gastrografin's utility beyond controlled clinical trials.

Main Methods:

  • Retrospective review of 1302 patients with partial small bowel obstruction across two hospitals.
  • Comparison of patients managed with a Gastrografin protocol versus standard care.
  • Exclusion criteria included recent bowel surgery or age under 18.
  • Statistical analysis using Fisher's Exact test and Mann-Whitney U test.

Main Results:

  • Patients on the Gastrografin protocol experienced shorter hospital stays (4.9 vs. 6.0 days, p < 0.001).
  • The protocol significantly lowered surgery rates (2% vs. 16%, p < 0.001).
  • Readmission rates for partial small bowel obstruction were similar between groups (8% vs. 5%, p = 0.26).

Conclusions:

  • A Gastrografin protocol effectively manages partial small bowel obstruction in a community setting.
  • This approach decreases the need for surgery and shortens hospital length of stay.
  • Gastrografin administration protocol is a valuable tool for community-based surgical services.