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Streptomyces coelicolor.

Paul A Hoskisson1, Gilles P van Wezel2

  • 1Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK.

Trends in Microbiology
|January 10, 2019
PubMed
Summary
This summary is machine-generated.

Streptomyces coelicolor A3(2) is a key model organism in Actinobacteria research, known for its complex life cycle and production of numerous natural products, including antibiotics. This strain, despite its name, is genetically closer to S. violaceoruber.

Keywords:
Actinobacteriaantibiotic productionsporulation

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Area of Science:

  • Microbiology
  • Genetics
  • Biochemistry

Background:

  • Streptomyces coelicolor A3(2) is a well-studied Actinobacteria species, crucial for understanding complex bacterial development and natural product biosynthesis.
  • The genus Streptomyces is the largest in Actinobacteria and produces a vast array of pharmaceutically important compounds.
  • Despite its common name, S. coelicolor A3(2) shares greater genetic similarity with Streptomyces violaceoruber ISP5049 than the species' type strain.

Purpose of the Study:

  • To highlight the significance of Streptomyces coelicolor A3(2) as a model organism.
  • To underscore the complex life cycle and natural product synthesis capabilities of Streptomyces.
  • To clarify the taxonomic relationship of S. coelicolor A3(2) within the Streptomyces genus.

Main Methods:

  • Literature review and comparative genomics.
  • Analysis of Streptomyces developmental biology.
  • Characterization of natural product pathways.

Main Results:

  • S. coelicolor A3(2) serves as a foundational model for studying Streptomyces genetics, development, and antibiotic production.
  • Streptomycetes exhibit a complex multicellular life cycle involving vegetative hyphae and spore formation.
  • This genus is a major source of clinically relevant antibiotics, anticancer agents, and immunosuppressants.

Conclusions:

  • Streptomyces coelicolor A3(2) remains an indispensable model organism in microbiology and biotechnology.
  • The study of Streptomyces continues to yield vital pharmaceutical compounds.
  • Understanding the genetics and development of S. coelicolor A3(2) is key to unlocking novel natural products.