Calcium signalling in T cells

Calcium (Ca²⁺) signalling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca²⁺ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity. Altered Ca²⁺ regulation in lymphocytes leads to various autoimmune, inflammatory and immunodeficiency syndromes. Several types of plasma membrane and organellar Ca²⁺-permeable channels are functional in T cells. They contribute highly localized spatial and temporal Ca²⁺ microdomains that are required for achieving functional specificity. While the mechanistic details of these Ca²⁺ microdomains are only beginning to emerge, it is evident that through crosstalk, synergy and feedback mechanisms, they fine-tune T cell signalling to match complex immune responses. In this article, we review the expression and function of various Ca²⁺-permeable channels in the plasma membrane, endoplasmic reticulum, mitochondria and endolysosomes of T cells and their role in shaping immunity and the pathogenesis of immune-mediated diseases.