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Related Experiment Video

Updated: Jan 31, 2026

Ex Vivo Imaging of Cell-specific Calcium Signaling at the Tripartite Synapse of the Mouse Diaphragm
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Calcium signalling in T cells.

Mohamed Trebak1, Jean-Pierre Kinet2

  • 1Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA. mtrebak@psu.edu.

Nature Reviews. Immunology
|January 10, 2019
PubMed
Summary

Calcium (Ca2+) signaling is crucial for immune cell function. This review explores how Ca2+ channels in T cells regulate immune responses and contribute to diseases.

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Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Calcium (Ca2+) signaling is vital for lymphocyte effector functions, including metabolism, proliferation, and cytokine secretion.
  • Dysregulation of Ca2+ homeostasis in lymphocytes is linked to autoimmune, inflammatory, and immunodeficiency disorders.

Purpose of the Study:

  • To review the expression and function of Ca2+-permeable channels in T cells.
  • To elucidate the role of Ca2+ microdomains in T cell signaling and immune responses.
  • To discuss the involvement of Ca2+ channels in immune-mediated diseases.

Main Methods:

  • Review of scientific literature on Ca2+ signaling in T cells.
  • Analysis of the roles of plasma membrane and organellar Ca2+ channels.
  • Discussion of T cell signaling pathways and immune pathogenesis.

Main Results:

  • T cells express various Ca2+-permeable channels in plasma membranes and organelles (ER, mitochondria, endolysosomes).
  • These channels generate localized Ca2+ microdomains essential for specific T cell functions.
  • Crosstalk, synergy, and feedback among Ca2+ microdomains fine-tune T cell responses.

Conclusions:

  • Ca2+ signaling via diverse channels is fundamental to T cell-mediated immunity.
  • Understanding these channels and microdomains is key to addressing immune-mediated diseases.